This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.
BNP Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human BNP (NP_002512.1).
Shipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
NPPB; BNP; natriuretic peptide B
WB, IF; Recommended dilution: WB 1:500 - 1:2000, IF 1:50 - 1:200