BackgroundInhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
DescriptionCTLA4 Recombinant Monoclonal Antibody [3B10]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP16410
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human CTLA4 (CD152)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesCytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152), CTLA4, CD152
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200