BackgroundNon-receptor tyrosine-protein kinase vital for cell growth, survival, adhesion, signaling, immune response, and axon guidance. Upon activation by PKA, associates with PTK2/FAK1 to promote focal adhesion activation. Phosphorylates proteins like CTNNB1, CTNND1, WAS, MAP2, MAPT, and AGAP2 to regulate cell adhesion, motility, cytoskeletal remodeling, and survival. Impacts kidney filtration by phosphorylating slit diaphragm components. Influences neural processes through phosphorylation of DPYSL2, ARHGAP32, and SNCA. Essential for T-cell differentiation and proliferation after T-cell receptor (TCR) stimulation. Facilitates CD28-induced VAV1 phosphorylation and negatively regulates TCR signaling through PAG1 phosphorylation.
DescriptionFYN Recombinant Monoclonal Antibody [1G3]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP06241
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Fyn
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesTyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn), FYN
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200