BackgroundRepressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
DescriptionEIF4EBP3 Polyclonal Antibody, HRP Conjugated. HRP. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDO60516
Purification>95%, Protein G purified
ImmunogenRecombinant Human Eukaryotic translation initiation factor 4E-binding protein 3 protein (1-100AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative Names4E-BP3, eIF4E-binding protein 3, EIF4EBP3
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000