Histone Acetylation Antibodies

Histone acetylation is a post-translational modification involving the addition of an acetyl group to the lysine residues of histone N-terminal tails, and its status can be studied with the use of histone acetylation antibodies.

This modification is typically associated with an increase in the level of gene expression, as it causes the chromatin to become more relaxed and accessible to the transcriptional machinery. For instance, acetylated histone marks such as H3K9ac, H3K14ac, and H3K27ac have been linked to an open chromatin configuration and active gene expression state.

Histone acetylation is mediated by enzymes known as histone acetyltransferases (HATs), which transfer the acetyl group from acetyl coenzyme A (acetyl-CoA) to the lysine residues on histones. Conversely, histone deacetylases (HDACs) remove the acetyl groups from histones, leading to a more tightly packed chromatin and a decrease in transcription. The balance between HATs and HDACs determines the overall level of histone acetylation and, in turn, the level of gene expression.

What makes buying antibodies from EpiGentek different?

At EpiGentek, we supply a collection of over 20,000 individual high-quality antibodies for our customers to ensure that our research customers find exactly what they need for their studies. In addition, we offer a variety of other benefits to help our customers in terms of affordability, convenience, and reliability. See why working with EpiGentek for your antibodies is the right choice:

• No Shipping & Handling Costs: we’ve waived all shipping and handling fees on our antibodies and antibody panel packs when selecting 2-day shipping (trial sizes not applicable).
• 100% Application Guarantee: your purchased antibodies are covered for 6-months past the date of purchase.
• Multiple Conjugates: we carry biotin, FITC and HRP conjugates for nearly all targets.
• Trial Sizes Available: 10 & 20 µl options available for thousands of antibodies in our catalog.