BackgroundTyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5.
DescriptionERBB3 Recombinant Monoclonal Antibody [6F6]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP21860
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human ErbB3
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesReceptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3), ERBB3, HER3
ApplicationELISA, IF; Recommended dilution: IF:1:20-1:200