BackgroundFunctions as a transcription corepressor, inhibiting transcriptional activity of sumoylated transcription factors. It can be directed to specific nuclear compartments, like nucleoli and PML nuclear bodies, affecting transcription there. It interacts with various proteins to modulate gene regulation, apoptosis, and histone deposition. It's also part of the ATRX:DAXX chromatin remodeling complex and plays roles in DNA repair and apoptosis pathways. It has both positive and negative effects on different signaling pathways and cellular processes.
DescriptionDAXX Recombinant Monoclonal Antibody [3A2]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ9UER7
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human DAXX
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesDeath domain-associated protein 6, Daxx, hDaxx, ETS1-associated protein 1, EAP1, Fas death domain-associated protein, DAXX, BING2, DAP6
ApplicationELISA