CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
Rabbit polyclonal antibody to Dnmt 3a
Recombinant protein of human DNMT3A
Mouse, rat, human
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Store at -20ºC (regular) or -80ºC (long term). Avoid freeze / thaw cycles
DNA (cytosine 5) methyltransferase 3 alpha antibody, DNA (cytosine-5)-methyltransferase 3A antibody, DNA cytosine methyltransferase 3A2 antibody, DNA methyltransferase 3a antibody, DNA methyltransferase HsaIIIA antibody, DNA MTase HsaI antibody, DNA MTase HsaIIIA antibody, DNM3A_HUMAN antibody, DNMT 3a antibody, DNMT antibody, DNMT3A2 antibody, M HsaIIIA antibody, MCMT antibody, Methyl CpG binding domain protein 3a antibody, OTTHUMP00000201149 antibody,DNMT3A2, M.HsaIIIA
WB: 1:50 - 1:200, IHC: 1:50 - 1:200, IF: 1:50 - 1:200
Fig. 1. Western blot analysis of extracts of various tissues, using DNMT3A antibody.
Fig. 2. Immunohistochemistry of paraffin-embedded human stomach cancer tissue using DNMT3A antibody.
Fig. 3. Immunofluorescence analysis of A549 cell using DNMT3A antibody. Blue: DAPI for nuclear staining.