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MGMT Polyclonal Antibody

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Western blot analysis of Hela cell lysate using MGMT Polyclonal Antibody.
Immunofluorescence analysis of U20S cell using MGMT Polyclonal Antibody. Blue: DAPI for nuclear staining.
Application: IF, IHC, WB
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
100% Guarantee: 6 months
Catalog No.SizePriceQty
A-1010-05050 µg $199.00 
A-1010-100100 µg $380.00 
Availability: Usually Ships in 3-4 Days 
Product Overview

Background
O6-methylguanine methyltransferase (MGMT) is a ubiquitous DNA repair protein that removes O6 -alkyl-guanine lesions, primarily O6 -methyl-guanine from damaged DNA. It is a major contributor to cellular protection from the mutagenic, carcinogenic, and cytotoxic effects of DNA alkylation. Also, MGMT is frequently silenced due to abnormal methylation during cancer development. Consequently, the loss of MGMT activity that made the cell more likely to become a cancer cell in the first place also makes tumor cells more sensitive to radiation therapy and certain alkylating drugs. 

Description
Rabbit polyclonal antibody to MGMT.

Purification
Affinity Purified

Specificity
Mouse, Rat, Human

Isotype
IgG

Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage
Store at -20℃. Avoid freeze / thaw cycles.

Alternative Names
6 O methylguanine DNA methyltransferase antibody, Agat antibody, AGT antibody, AI267024 antibody, EC 2.1.1.63 antibody, Methylated DNA protein cysteine methyltransferase antibody, Methylguanine DNA methyltransferase antibody, MGC107020 antibody, MGMT antibody, O 6 methylguanine DNA alkyltransferase antibody, O 6 methylguanine DNA methyltransferase antibody

Application
WB (1:500 - 1:2000), IHC (1:50 - 1:200), IF (1:50 - 1:200)

User Guide & MSDS

[User Guide]*
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