LSD1 is a nuclear homolog of amine oxidases and functions as a histone demethylase and transcriptional corepressor. LSD1specifically demethylates histone H3 lysine 4, which is linked to active transcription. LSD1 is highly conserved between organisms ranging from the fission yeast saccharomyces pombe to humans. LSD1 associates with other histone-modifying enzymes such as histone deacetylases and methyltransferases. In concert with transcription repression, loss of LSD1 function leads to derepression of genes regulated by Co-REST, a protein involved in gene silencing and a member of the LSD1.
Rabbit polyclonal antibody to LSD1
Protein A purified
Positive in human
0.1% Sodium Azide, PBS
4ºC, stable for 6 months from the date of shipment. For long-term storage, aliquot and store at -20ºC. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance
Amine oxidase flavin containing domain 2 antibody, AOF 2 antibody, BHC110 antibody, BRAF35 HDAC complex protein BHC110 antibody, FAD binding protein BRAF35 HDAC complex 110 kDa subunit antibody, Flavin containing amine oxidase domain containing protein 2 antibody, KDM 1 antibody, KIAA0601 antibody, LSD 1 antibody, Lysine (K) specific demethylase 1A antibody, Lysine specific histone demethylase 1 antibody
WB: 1:200-1:500, ELISA: 1:1000-1:2000
Fig. 1. WB analysis of LSD1 Antibody with mouse brain cell lysates (A-3018).