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Histone H4K8ac (Acetyl H4K8) Polyclonal Antibody

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Application: ChIP, ChIP-Seq, ELISA, IF, IHC, IP, WB
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Broad Range, Human, Mouse, Rat
Application Guarantee: 6 months
Catalog No.SizePriceQty
A-4028-05050 µg $149.00 
A-4028-100100 µg $289.00 
Availability: Usually Ships In 1-2 Days 
Product Overview

Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.

Concentration
1mg/ml

Description
Rabbit polyclonal antibody raised against a synthetic peptide corresponding to N-terminus of histone H4 acetylated at K8, ChIP-grade

Purification
Affinity purified

Specificity
Broad Range, Mouse, Rat, Human

Isotype
IgG

Immunogen 
A synthetic acetylated peptide corresponding to residues surrounding K8 of human H4

Formulation 
PBS (pH 7.5), 0.1% gelatin

Storage
4°C, stable for 1 year from the date of shipment. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance

Alternative Names
H4K8ac antibody; H4K8a antibody;H4; H4/n; H4F2; H4FN; FO108; HIST2H4

Application 
WB 1:1000 - 1:3000
IHC 1:200 - 1:500
IF 1:500 - 1:1000
IP 1:200 - 1:500
ChIP 1:20 - 1:50
ChIP-Seq 1:20 - 1:50

Fig. 1. Western blot analysis of extracts of 293T cell line and H4 protein expressed in E.coli, using Histone H4K8ac (Acetyl H4K8) Polyclonal Antibody.

 

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