SUV39H1 is a human homologue of the dominant Drosophila PEV modifier Su(var)3–9 and is composed of 412 amino acid residues. SUV39H1, as a histone methyltransferase, selectively methylates histone H3 on lysine 9, which generates a binding site for HP1 proteins. HP1 proteins are a family of heterochromatic adaptor molecules involved in both gene silencing and supra-nucleosomal chromatin structure. SUV39H1 plays in important role in histone modification and regulation of gene expression.
Mouse monoclonal antibody to SUV39H1, ChIP-grade
Protein A purified
0.1% Sodium Azide, 0.1% gelatin, PBS
4ºC, stable for 1 year from the date of shipment. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance
H3 K9 HMTase1 antibody, Histone H3 K9 methylation antibody, Histone H3 Lys 9 methylation antibody, Histone H3-K9 methyltransferase 1 antibody, KMT1 A antibody, KMT1A antibody, Lysine N methyltransferase 1A antibody, MG44 antibody, mIS6 antibody, Position-effect variegation 3-9 homolog antibody, Su(var)3 9 homolog 1 antibody, Suppressor of variegation 3 9 homolog 1 (Drosophila) antibody
WB: 1:200-1:500, IHC: 1:100-1:200, ELISA: 1:500-1:1000, IP: 4 µg/106 cells; IF: 1:100 – 1:500
Fig. 1. WB analysis of SUV39H1 Monoclonal Antibody with SUV39H1 overexpressed 293T cell lysates (A-3009).