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Acetyl Histone H4K16 Polyclonal Antibody

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Application: ELISA, IF, IHC, IP, WB
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Goat
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
Application Guarantee: 6 months
Catalog No.SizePriceQty
A-4030-05050 µg $149.00 
A-4030-100100 µg $289.00 
Availability: Usually Ships In 1-2 Days 
Product Overview

Background
Histone H4- along with H2A, H2B, and H3- is involved in the structure of chromatin in eukaryotic cells. Histone H4 can undergo several different types of epigenetic modifications that influence cellular processes. These modifications including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation occur on the N-terminal tail domains of histone H4, which results in remodeling of the nucleosome structure into an open conformation more accessible to transcription complexes. In most species, histone H4 is primarily acetylated at lysine 5, 8, 12, and 16. 

Concentration
0.2 mg/ml

Description
Goat polyclonal antibody raised against a synthetic peptide corresponding to N-terminus of histone H4 acetylated at K16

Purification
Protein A purified

Specificity
Detects histone H4 only when acetylated at K16 in mouse, rat, and human.

Isotype
IgG

Formulation 
PBS (pH 7.5), 0.1% gelatin

Storage
4°C, stable for 1 year from the date of shipment. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance

Alternative Names
H4K16ac antibody, H4K16a antibody

Application 
WB: 1:200-1:1000, IF: 1:100-1:500, IHC: 1:100-1:500, ELISA: 1:1000-1:2000, IP: 2 μg/106 cells

Fig. 1. WB analysis of Acetyl Histone H4K16 Polyclonal Antibody with NIH-3T3 cell lysates (A-4030).

 

User Guide & MSDS

[User Guide]*
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Product Citations

Gonneaud A et. al. (September 2015). Loss of histone deacetylase Hdac1 disrupts metabolic processes in intestinal epithelial cells. FEBS Lett. 589(19 Pt B):2776-83.

Ding L et. al. (September 2012). Changes in histone acetylation during oocyte meiotic maturation in the diabetic mouse. Theriogenology. 78(4):784-92.

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