BackgroundThe protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
DescriptionSMARCE1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. PBS with 0.02% sodium azide, 50% glycerol, pH7.3
SpecificityHuman, Mouse
IsotypeIgG
Uniprot IDQ969G3
PurificationAffinity Purified
ImmunogenRecombinant Protein of Human SMARCE1
StorageShipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
Alternative NamesBAF57
ApplicationWB, IHC, IF; Recommended dilution: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200