BackgroundSMARCA4 is a member of the SWI/SNF family of proteins that have helicase and ATPase activities and are believed to regulate transcription of certain genes by changing the chromatin structure around those genes. SMARCA4 can bind BRCA1 and can regulate the expression CD44, a tumorigenic protein. Abnormalities in this gene are associated with rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms exist for this gene.
DescriptionSMARCA4 Polyclonal Antibody . Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDP51532
PurificationAffinity Purified
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 680-770 of human BRG1/SMARCA4 (NP_003063.2)
StorageShipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
Alternative NamesBAF190, BRG1, FLJ39786, SNF2, SNF2-BETA, SNF2L4, SNF2LB, SWI2, hSNF2b
ApplicationWB, IHC, IF, IP