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PRMT5 Polyclonal Antibody

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Western blot analysis of PRMT5 Polyclonal Antibody.
Immunohistochemistry - PRMT5 Polyclonal Antibody
Immunohistochemistry - PRMT5 Polyclonal Antibody
Immunohistochemistry - PRMT5 Polyclonal Antibody
Application: IF, IHC, WB
Areas of Research: Histone Methylation & Demethylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Monkey, Mouse, Rat
100% Guarantee: 6 months
Catalog No.SizePriceQty
A-3005-05050 µl $199.00 
A-3005-100100 µl $391.00 
Availability: Usually Ships in 3-4 Days 
Product Overview

Background
Human Skb1Hs methyltransferase (also called JBP1), a homologue of yeast protein Skb1 and Hsl7p, is composed of 637 amino acid residues and contains motifs conserved among protein methyltransferases. It methylates histones and MBP in vitro. Yeast Hsl7p is involved in regulation of cell cycle progression through G2 by negatively regulating Swe1p, a protein tyrosine kinase that phosphorylates and inhibits Cdc28p. An Hsl7p homologue, Skb1, was identified in fission yeast by virtue of its yeast two-hybrid interaction with Shk1p, a p21 (cdc42p/Rac) activated kinase (PAK). Both proteins belong to the protein methyltransferase superfamily. Interestingly, human Skb1Hs methyltransferase was shown to interact with Jak kinases. This suggests the possibility that the Skb1Hs methyltransferase could link Jak to a PAK signaling pathway in mammalian cells.

Description
PRMT5 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Specificity
Human, Mouse, Rat, Monkey

Isotype
IgG

Uniprot ID
O14744

Purification
Affinity Purified

Immunogen
Synthetic Peptide of Human PRMT5

Storage
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.

Alternative Names
72 kDa ICln binding protein antibody, ANM5_HUMAN antibody, Histone synthetic lethal 7 S. cerevisiae homolog of antibody, Histone-arginine N-methyltransferase PRMT5 antibody, HMT1 hnRNP methyltransferase like 5 antibody, HRMT1L5 antibody, IBP72 antibody, Jak-binding protein 1 antibody, JBP 1 antibody, PRMT 5 antibody, Protein arginine N methyltransferase 5 N terminally processed antibody, S. Pombe antibody, Shk1 kinase binding protein 1 homolog antibody, SKB 1 antibody, SKB1Hs antibody

Application
WB, IHC, IF

User Guide & MSDS

[User Guide]*
*Always use the actual User Guide that shipped with your product. Is the above file locked? You can also request user guides by emailing info@epigentek.com along with your contact information and institution name.

Product Citations

Scaglione A et. al. (July 2018). PRMT5-mediated regulation of developmental myelination. Nat Commun. 9(1):2840.

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