The Set1/COMPASS histone methyltransferase complex contains the SET1 histone methyltransferase protein. It functions as a transcriptional co-activator and methylates histone H3 at Lys4 (H3K4). Although first identified in yeast, SET1-related proteins are also found within mammals, including proteins SET1A, SET1B, MLL1, MLL2, MLL3, and MLL4. These proteins work together in a complex to methylate histone H3 at Lys4. In addition, SET1/COMPASS histone methyltransferase complexes are thought to play a role in leukemogenesis due to a significant amount of hematological malignancies containing MLL translocations.
Rabbit polyclonal antibody to SET1
Protein A purified
Positive in human
0.1% Sodium Azide, PBS
4ºC, stable for 6 months from the date of shipment. For long-term storage, aliquot and store at -20ºC. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance
Histone-lysine N-methyltransferase SETD1A antibody, hSET1A antibody, KMT2F antibody, Lysine N methyltransferase 2F antibody, SET domain containing protein 1A antibody, Set1 Ash2 histone methyltransferase complex subunit SET1 antibody, SET1A antibody, SETD1A antibody
WB: 1:200-1:500, IHC: 1:100, ELISA: 1:1000-1:2000
Fig. 1. WB analysis of SET1 Polyclonal Antibody with mouse heart cell lysates (A-3011).