COX-2 Polyclonal Antibody

Background
Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS), is a key enzyme in the conversion of arachidonic acid to Prostaglandin H2. Two isoforms that exist for this enzyme are COX-1 and COX-2. COX-1 is involved in the synthesis of prostaglandin and thromboxane in many cell types, including gastro-intestinal tract and blood platelets. COX-2 is an inducible enzyme that plays a significant role in the biosynthesis of prostaglandins (PGs) under acute inflammatory conditions. COX-2 can be induced by numerous stimuli and has been found to be overexpressed in adenocarcinomas and other tumors. COX-2 inhibitors have analgesic and anti-inflammatory function by blocking the transformation of arachidonic acid into prostaglandin H2 selectively. 

Description
Rabbit polyclonal antibody to COX-2

Formulation
Liquid. In PBS.

Immunogen
Synthetic peptide corresponding to a portion of C-terminal mouse COX-2.

Specificity
Human, Mouse, Sheep

Purification
Serum

Storage
Store at -80°C. Avoid multiple freeze/thaw cycles.

Alternative Names
Prostaglandin H2 synthase, Cyclooxygenase-2

Application
IHC, IP, WB