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Epigentek Inc. currently offers innovative DNA modification products at very competitive prices. The Methylamp™ kits are designed using our proprietary technology, which would be the best candidates for your gene methylation research.
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Protein-DNA interaction plays a critical role for cellular functions such as gene transcription and epigenetic silencing. Our EpiQuik™ Chromatin Immunoprecipitation kit uses a unique procedure and composition to investigate protein-DNA interaction efficiently. The kit is compatible with all DNA amplification-based approaches, and has the fastest procedure (less than 5 hours) on the market with simple, reliable, and consistent assay conditions.
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DNA/histone methyltransferases play a critical role in regulation of gene transcription through DNA or histone methylation. DNA methylation leads to gene silencing and tumorigenesis. Histone methylation, depending on the targeting sites, causes transcription repression or activation. Determination of the methyltrasferase activity has become important in studying epigenetic regulation of genes and inhibitor discovery. We provide you the non-isotopic DNA/histone methyltransferase assay kits as powerful tools for your epigenetic research.
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Histone deacetylases (HDACs) play a critical role in gene transcriptional regulation. Abnormal gene silencing by recruited HDAC activity has been linked to the pathogenesis of many diseases, especially cancer. The determination of the activity of HDAC and the potency of its inhibitors becomes important in epigenetic research. Our HDAC activity and inhibitor assay kits will provide you the fastest and most efficient tool for your epigenetic research and, especially, drug discovery.
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Targeted gene knockdown using small interfering RNA (siRNA) or antisense oligonucleotide has been valuable technology for studying gene function. Gene knockdown leads to reduction in mRNA and subsequently protein expression. Our kit uses unique procedures/compositions to directly quantify gene knockdown effects at the protein level by using various mammalian cell or tissue lysates. These kits would provide simple and rapid tools for measuring levels of the gene expression/silencing.
We also provide related products for epigenetic research which include the kits for nuclear protein extraction, measurement of cell proliferation/cytotoxicity, determination of oxidative stress-induced epigenetic damage of DNA, and more. All of these kits are more rapid, simple, and efficient than methods currently used.
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