TMEM173 Recombinant Monoclonal Antibody [7C7]

Background
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

Description
TMEM173 Recombinant Monoclonal Antibody [7C7]. Unconjugated. Raised in: HEK293F Cell.

Formulation
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity
Human

Isotype
Rabbit IgG

Uniprot ID
Q86WV6

Purification
Affinity Chromatography

Immunogen
A synthesized peptide derived from human TMEM173

Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Alternative Names
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173), TMEM173, ERIS MITA STING

Application
ELISA, WB; Recommended dilution: WB:1:500-1:5000