NPC1L1 Recombinant Monoclonal Antibody [4B10]

Background
Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.

Description
NPC1L1 Recombinant Monoclonal Antibody [4B10]. Unconjugated. Raised in: HEK293F Cell.

Formulation
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity
Human

Isotype
Rabbit IgG

Uniprot ID
Q9UHC9

Purification
Affinity Chromatography

Immunogen
A synthesized peptide derived from human NPC1L1

Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Alternative Names
NPC1-like intracellular cholesterol transporter 1 (Niemann-Pick C1-like protein 1), NPC1L1

Application
ELISA, IHC; Recommended dilution: IHC:1:50-1:200