Histone acetylase (HATs) and deacetylases (HDACs) play a critical role in gene transcriptional regulation. Abnormal gene silencing by recruited HAT or HDAC activity has been linked to the pathogenesis of many diseases, especially cancer. The determination of the activity of HAT and HDAC and the potency of its inhibitors becomes important in epigenetic research. Our HAT and HDAC activity and inhibitor assay kits, combining with our histone acetylation pattern assay kits will provide you the fastest and most efficient tool for your epigenetic research and, especially, drug discovery.

Histone Acetylase (HAT) Assay Rapid and efficient assay for HAT activity or level. High throughput in microplate format. Suitable for both purified enzyme or nuclear extracts. Histone Deacetylase (HDAC) Assay Rapid and efficient assay for HDAC activity or level. High throughput in microplate format. Suitable for both purified enzyme or nuclear extracts. Histone Acetylation Quantification Innovative colorimetric and fluorometric assays. Quantitate all acetylation patterns. Fast and high throughput. Accessory Reagents Various buffers and substrates for acetylation and deacteylation.