Comprehensive Epigenetic Services for Genome-Wide DNA Hydroxymethylation Analysis
EpiGentek’s DNA hydroxymethylation service platforms will specifically detect 5-hydroxymethylcytosine (5-hmC) at either a multi base resolution or single base resolution without cross-reactivity to methylated cytosine or unmethylated cytosine. From start to finish, send in your samples and receive complete bioinformatic analysis and publication-ready results for your DNA hydroxymethylation research.
Since cytosine hydroxymethylation was discovered in mammal cells, this epigenetic modification has become an invaluable mechanism giving researchers insight into DNA methylation and its effects on cellular function, disease, and various biological processes. Because 5-hmC plays a role in regulation of DNA methylation and chromatin remodeling, identifying hydroxymethylation status in specific gene loci would allow researchers to better understand methylation-based epigenetic regulation of gene functions. Evidence shows it functions in the renewal of stem cells, embryonic development, cancer, and the development of neurological disorders such as Alzheimer’s disease and Huntington’s disease.