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Splitomicin

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Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: DMSO
100% Guarantee: 6 months
Catalog No.SizePriceQty
M45001-15 mg $261.00  Discontinued
Availability: Discontinued 
Product Overview

Alternative Names
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Description
Splitomicin  is a cell-permeable lactone that acts as a selective inhibitor of NAD+ dependent histone deacetylase activity of Sir2 protein. It creates a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.

CAS Number
5690-03-9

Chemical Formula
C13H10O2

Molecular Weight
198.2

Size
5 mg

Purity
≥98%

Solubility
DMSO

Storage Temp
-20°C

User Guide & MSDS

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