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Geneticists Victor Ambros and Gary Ruvkun have been awarded the 2024 Nobel Prize in Physiology or Medicine for their discovery of microRNAs, small RNA molecules that play a crucial role in gene regulation. Their work revealed that microRNAs influence the translation of messenger RNAs, thereby controlling protein production in diverse organisms, from roundworms to humans. Since their first discovery in Caenorhabditis elegans, microRNAs have been implicated in numerous biological processes, including development, physiology, and disease. This unexpected finding of a novel gene regulatory mechanism reshaped our understanding of cellular processes and sparked widespread interest in RNA biology and its potential therapeutic applications.
Just as microRNAs add a layer of complexity to gene expression, RNA methylation plays a complementary role in regulating RNA stability, localization, and interaction with other molecules. EpigenTek supports this rapidly evolving field by providing products that enable researchers to investigate modifications like m6A and 5mC and their impact on RNA function and gene expression. Our kits for RNA isolation, global m6A/5mC RNA quantification, m6A methylase/demethylase enzyme activity assessment, RNA bisulfite conversion, m6A RNA enrichment (MeRIP), and MeRIP-seq, as well as our highly specific anti-m6A antibodies, are designed to facilitate your RNA methylation studies from start to finish. With EpigenTek’s products, researchers can uncover the broader landscape of RNA regulation and its implications for health and disease, contributing to a more comprehensive understanding of gene expression mechanisms in human biology.