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RNA Methylation

RNA methylation is a reversible post-translational modification to RNA that epigenetically impacts numerous biological processes. It occurs in different RNAs including tRNA, rRNA, mRNA, tmRNA, snRNA, snoRNA, miRNA, and viral RNA. Different catalytic strategies are employed for RNA methylation by a variety of RNA-methyltransferases.

N6-methyladenosine (m6A) is the most common and abundant methylation modification in RNA molecules present in eukaryotes and accounts for more than 80% of all RNA methylation. It may be referred to as the “fifth RNA base” and has broad roles in regulating embryonic development and cell fates. In particular, this RNA modification is thought to be important for mRNA regulation due to enrichment of m6A at 3’UTRs. It has also been linked to cancers including leukemia, breast cancer, and prostate cancer.

m6A
N6-methyladenosine (m6A)
5-methylcytosine (5-mC) is an epigenetic mark that also commonly occurs in various RNA molecules. Researchers are able to bisulfite convert RNA, perform RT-PCR amplification, cloning, and sequencing to gain information about RNA cytosine methylation states. By treating RNA with bisulfite, cytosine residues are deaminated to uracil while leaving 5-methylcytosine intact.

Recent data strongly suggest that m6A and 5-mC RNA methylation affects the regulation of various biological processes such as RNA stability and mRNA translation, and that abnormal RNA methylation contributes to etiology of human diseases. Furthermore, loss of 5-mC in vault RNAs causes aberrant processing into Argonaute-associated small RNA fragments that can function as microRNAs. Researchers continue to investigate m6A and 5-mC in RNA to uncover the mysteries of RNA methylation.
Result Pages:  1  Displaying 1 to 7 (of 7 products)
Image Description Cat. No. Size Price
Methylamp RNA Bisulfite Conversion Kit
Methylamp RNA Bisulfite Conversion Kit

Input Type: RNA
Research Area: RNA Methylation
Target Application: Sample Modification
Vessel Format: Columns/Tubes
P-9003-05050 reactionsView
Research Kits
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)

Citations (13) | (3)
Input Type: RNA
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9005-4848 reactionsView
P-9005-9696 reactionsView
Research Kits
EpiNext 5-mC RNA Bisulfite-Seq Easy Kit (Illumina)
EpiNext 5-mC RNA Bisulfite-Seq Easy Kit (Illumina)

Input Type: RNA
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9007-1212 reactionsView
P-9007-2424 reactionsView
Research Kits
EpiQuik m6A RNA Methylation Quantification Kit (Fluorometric)
EpiQuik m6A RNA Methylation Quantification Kit (Fluorometric) new product

Input Type: RNA
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9008-4848 assaysView
P-9008-9696 assaysView
Research Kits
MethylFlash 5-mC RNA Methylation ELISA Easy Kit (Fluorometric)
MethylFlash 5-mC RNA Methylation ELISA Easy Kit (Fluorometric)

Citations (2)
Input Type: RNA
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9009-4848 reactionsView
P-9009-9696 reactionsView
Research Kits
Epigenase m6A Demethylase Activity/Inhibition Assay Kit (Colorimetric)
Epigenase m6A Demethylase Activity/Inhibition Assay Kit (Colorimetric) new product

Input Type: Nuclear Extracts or Purified Enzymes
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9013-4848 assaysView
P-9013-9696 assaysView
Research Kits
MethylFlash Urine N6-methyladenosine (m6A) Quantification Kit (Colorimetric)
MethylFlash Urine N6-methyladenosine (m6A) Quantification Kit (Colorimetric) new product

Input Type: Urine
Research Area: RNA Methylation
Target Application: Amount Quantitation
Vessel Format: 96-Well Plate
P-9015-4848 assaysView
P-9015-9696 assaysView
Research Kits
Result Pages:  1  Displaying 1 to 7 (of 7 products)
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