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Phosphatase Antibodies

Phosphorylation is a major post-translational modification to proteins and controls cell signaling and induction of cell proliferation, differentiation, cell death and other biological processes. Phosphatases reverse phosphorylation by removing the phosphate group added by kinases mostly to serine, threonine or tyrosine residues in a protein. Thus phosphatases have a critical role in regulating cell signaling, as generally reversal of the phosphorylation indicates a switching off of the signal. Uncontrolled or constitutive signaling by cell surface receptors may lead to increased proliferation, among other outcomes, and could lead to the pathogenesis of cancer and other diseases. Therefore, after phosphorylation and protein activation by kinases, the signal must return to the resting or inactivated state through dephosphorylation catalyzed by phosphatases.

Two important phosphatases include the serine/threonine protein phosphatase 2A (PP2A) and phosphatase and tensin homolog (PTEN). PP2A is a key phosphatase as it catalyzes dephosphorylation of many proteins, but also dephosphorylates the main protein kinases responsible for activation of major signaling pathways, including AKT, ERK MAP kinase and Protein kinase C (PKC) family members. PTEN dephosphorylates proteins, as well as the phospholipid phosphatidylinositol (3,4,5)-trisphosphate (PIP3), which induces inhibition of signaling by AKT, a critical pathway involved in cellular growth and proliferation. PTEN is a tumor suppressor frequently mutated and involved in the pathogenesis and progression of several cancers.
Result Pages:  1  2  3  4  5 ...  [Next >>]  Displaying 1 to 20 (of 182 products)
PTPMT1 Polyclonal Antibody, FITC Conjugated
PTPMT1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Metabolism, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A55960-05050 µg $256.00 Add to Cart
A55960-100100 µg $359.00 Add to Cart
Antibodies
PTPMT1 Polyclonal Antibody, HRP Conjugated
PTPMT1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Metabolism, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A55959-05050 µg $256.00 Add to Cart
A55959-100100 µg $359.00 Add to Cart
Antibodies
PTPN3 Polyclonal Antibody
PTPN3 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A69667-02020 µg $99.00 Add to Cart
A69667-05050 µg $249.00 Add to Cart
A69667-100100 µg $399.00 Add to Cart
Antibodies
PTPN3 Polyclonal Antibody, Biotin Conjugated
PTPN3 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69670-05050 µg $249.00 Add to Cart
A69670-100100 µg $399.00 Add to Cart
Antibodies
PTPN3 Polyclonal Antibody, FITC Conjugated
PTPN3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69669-05050 µg $249.00 Add to Cart
A69669-100100 µg $399.00 Add to Cart
Antibodies
PTPN3 Polyclonal Antibody, HRP Conjugated
PTPN3 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69668-05050 µg $249.00 Add to Cart
A69668-100100 µg $399.00 Add to Cart
Antibodies
PTPN5 Polyclonal Antibody
PTPN5 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A56098-02020 µg $99.00 Add to Cart
A56098-05050 µg $256.00 Add to Cart
A56098-100100 µg $359.00 Add to Cart
Antibodies
PTPN5 Polyclonal Antibody, Biotin Conjugated
PTPN5 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A56101-05050 µg $256.00 Add to Cart
A56101-100100 µg $359.00 Add to Cart
Antibodies
PTPN5 Polyclonal Antibody, FITC Conjugated
PTPN5 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A56100-05050 µg $256.00 Add to Cart
A56100-100100 µg $359.00 Add to Cart
Antibodies
PTPN5 Polyclonal Antibody, HRP Conjugated
PTPN5 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A56099-05050 µg $256.00 Add to Cart
A56099-100100 µg $359.00 Add to Cart
Antibodies
PTPN6 Polyclonal Antibody
PTPN6 Polyclonal Antibody

Application: ELISA, IF, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A55619-02020 µg $99.00 Add to Cart
A55619-05050 µg $256.00 Add to Cart
A55619-100100 µg $359.00 Add to Cart
Antibodies
PTPN6 Polyclonal Antibody, Biotin Conjugated
PTPN6 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A55622-05050 µg $256.00 Add to Cart
A55622-100100 µg $359.00 Add to Cart
Antibodies
PTPN6 Polyclonal Antibody, FITC Conjugated
PTPN6 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A55621-05050 µg $256.00 Add to Cart
A55621-100100 µg $359.00 Add to Cart
Antibodies
PTPN6 Polyclonal Antibody, HRP Conjugated
PTPN6 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A55620-05050 µg $256.00 Add to Cart
A55620-100100 µg $359.00 Add to Cart
Antibodies
PTPRN Polyclonal Antibody
PTPRN Polyclonal Antibody

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A60470-02020 µg $99.00 Add to Cart
A60470-05050 µg $256.00 Add to Cart
A60470-100100 µg $359.00 Add to Cart
Antibodies
PTPRN Polyclonal Antibody, Biotin Conjugated
PTPRN Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A60471-05050 µg $256.00 Add to Cart
A60471-100100 µg $359.00 Add to Cart
Antibodies
PTPRN Polyclonal Antibody, FITC Conjugated
PTPRN Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A60472-05050 µg $256.00 Add to Cart
A60472-100100 µg $359.00 Add to Cart
Antibodies
PTPRN Polyclonal Antibody, HRP Conjugated
PTPRN Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A60473-05050 µg $256.00 Add to Cart
A60473-100100 µg $359.00 Add to Cart
Antibodies
PTPRR Polyclonal Antibody
PTPRR Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A55271-02020 µg $99.00 Add to Cart
A55271-05050 µg $256.00 Add to Cart
A55271-100100 µg $359.00 Add to Cart
Antibodies
PTPRR Polyclonal Antibody, Biotin Conjugated
PTPRR Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A55274-05050 µg $256.00 Add to Cart
A55274-100100 µg $359.00 Add to Cart
Antibodies
Result Pages:  1  2  3  4  5 ...  [Next >>]  Displaying 1 to 20 (of 182 products)
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