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Modulators & Inhibitors

Modulators & Inhibitors

DNA Methylation
DNA methylation modulators and inhibitors are useful for studying the common epigenetic mechanism known as DNA methylation, which entails the addition of a methyl group onto DNA. Using enzyme inhibition assays, various DNA methylation modulators and inhibitors have been shown to display antitumor and antioxidant properties, inhibit telomerase and DNA methyltransferase (DNMT) activity, and block activation of various receptors.

Histone Acetylation
Modulators and inhibitors are used in enzyme inhibition assays to study histone acetylation, or the addition of an acetyl group on a histone, which then affects the regulation of transcription through chromatin remodeling. Certain epigenetic modulators and inhibitors specific to histone acetylation studies have been shown to inhibit histone acetyltransferases (HATs) such as p300/CBP associated factor histone acetyltransferase, inhibit the transcription factor NF kappa B, promote apoptosis thr...

Histone Deacetylation
Modulators and inhibitors are used in enzyme inhibition assays to study histone deacetylation, or the removal of an acetyl group on a histone, which impacts the regulation of DNA expression. Histone deacetylation modulators and inhibitors inhibit histone deacetylases (HDACs) also called lysine deacetylases (KDACs). They are crucial to advancing epigenetic research in cell cycle regulation, cell proliferation, and development of cancer.

Histone Demethylation
Histone demethylation is defined as the removal of methyl groups from histone proteins by histone demethylases (KDMs), which affects the inactivation of chromatin and therefore gene expression. Histone demethylation modulators and inhibitors inhibit histone demethylases (HDMs) and offer insight into diseases such as breast cancer, prostate cancer, and lung cancer that are related to histone demethylation.

Histone Methylation
Histone methylation is described as the transfer of methyl groups to histone proteins (commonly H3 and H4) by histone methyltransferases (HMTs), which affects the activation of chromatin and therefore gene expression. Histone methylation modulators and inhibitors inhibit histone methyltransferases and allow researchers to study diseases, especially cancer, that are related to histone methylation.

Histone Phosphorylation
Histone phosphorylation has been implicated in numerous processes such as transcription, DNA repair, cell cycle progression and apoptosis, and chromosome condensation. These histone phosphorylation modulators and inhibitors act to inhibit proteases and phosphatases for research investigating diseases connected to phosphorylation such as Alzheimer’s and Huntington’s disease.

Result Pages:  1  2  [Next >>]  Displaying 1 to 20 (of 22 products)
Image Description Cat. No. Size Price
5-Aza-2'-deoxycytidine
5-Aza-2'-deoxycytidine

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: DNA Methylation
Solubility: DMSO
M22000-150 mgViewDiscontinued
Modulators & Inhibitors
5-Azacytidine
5-Azacytidine

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: DNA Methylation
Solubility: DMSO
M22001-11 gViewDiscontinued
Modulators & Inhibitors
Anacardic Acid
Anacardic Acid

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: DMSO, Ethanol, Other
M37000-15 mgViewDiscontinued
Modulators & Inhibitors
APHA Compound 8
APHA Compound 8

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: DMSO
M45003-11 mgViewDiscontinued
Modulators & Inhibitors
Aurora A Inhibitor I
Aurora A Inhibitor I

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Phosphorylation
Solubility: DMSO
M75000-15 mgViewDiscontinued
Modulators & Inhibitors
C646, p300/CBP Inhibitor
C646, p300/CBP Inhibitor

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: DMSO
M31000-11 mgViewDiscontinued
Modulators & Inhibitors
Cambinol
Cambinol

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: DMSO, Ethanol
M47000-15 mgViewDiscontinued
Modulators & Inhibitors
Curcumin
Curcumin

Citations (1)
Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: DMSO, Ethanol, Other, Water
M35000-11 gViewDiscontinued
Modulators & Inhibitors
DPQ
DPQ

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Phosphorylation
Solubility: DMSO
M71000-11 mgViewDiscontinued
Modulators & Inhibitors
DR2313
DR2313

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Phosphorylation
Solubility: Water
M75002-110 mgViewDiscontinued
Modulators & Inhibitors
Epigallocatechin Gallate
Epigallocatechin Gallate

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: DNA Methylation
Solubility: DMSO, Ethanol
M21000-150 mgViewDiscontinued
Modulators & Inhibitors
Ginkgolic acid
Ginkgolic acid

Application: Enzyme Activation
Molecular Weight: 100-500
Research Area: Histone Phosphorylation
Solubility: DMSO, Ethanol
M75004-15 mgViewDiscontinued
Modulators & Inhibitors
MLN8237 (Alisertib)
MLN8237 (Alisertib)

Application: Enzyme Inhibition
Molecular Weight: >500
Research Area: Histone Phosphorylation
Solubility: DMSO, Ethanol, Water
M76000-15 mgViewDiscontinued
Modulators & Inhibitors
Pargyline
Pargyline

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Methylation
Solubility: DMSO, Ethanol, Water
M55001-1500 mgViewDiscontinued
Modulators & Inhibitors
SAHA
SAHA

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: DMSO, Ethanol
M41000-210 mgViewDiscontinued
Modulators & Inhibitors
Sodium Butyrate
Sodium Butyrate

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: Water
M41001-11 gViewDiscontinued
Modulators & Inhibitors
Splitomicin
Splitomicin

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: DMSO
M45001-15 mgViewDiscontinued
Modulators & Inhibitors
Trans-2-Phenylcyclopropylamine hydrochloride
Trans-2-Phenylcyclopropylamine hydrochloride

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Methylation
Solubility: DMSO, Water
M55000-1250 mgViewDiscontinued
Modulators & Inhibitors
Trichostatin A
Trichostatin A

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: DMSO, Ethanol, Other
M45000-11 mgViewDiscontinued
Modulators & Inhibitors
Valproic Acid
Valproic Acid

Citations (1) | (1)
Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: Water
Modulators & Inhibitors
Result Pages:  1  2  [Next >>]  Displaying 1 to 20 (of 22 products)
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