Alternative NamesAlisertibDescriptionMLN8237 is a selective Aurora kinase A inhibitor with median IC50 of 61 nM. MLN8237 (Alisertib) is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the Aurora A kinase (serine/threonine protein kinase) with potential antineoplastic activity. MLN8237 (Alisertib) binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. CAS Number1028486-01-2Chemical FormulaC27H20ClFN4O4Molecular Weight518.92
Size5 mgPurity99.27%SolubilityDMSO ≥44mg/mL Water <1mg/mL Ethanol <1mg/mLStorage Temp-20°C