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KDM3B Polyclonal Antibody

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Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using KDM3B Polyclonal Antibody at dilution 1/40.
Gel: 6% SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, 293T cells, mouse skeletal muscle tissue
Primary antibody: KDM3B Polyclonal Antibody at dilution 1/1000
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
Application: ELISA, IHC, WB
Areas of Research: Histone Methylation & Demethylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse
100% Guarantee: 6 months
Catalog No.SizePriceQty
A-3703-05050 µlView
Product Overview

Background
JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression.

Description
KDM3B Polyclonal Antibody. Unconjugated. Raised in Rabbit.

Concentration
Inquire

Formulation
Liguid. -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Isotype
IgG

Uniprot ID
Q7LBC6

Immunogen
Fusion protein of human KDM3B

Specificity
Human, Mouse

Purification
Affinity Purified

Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Alternative Names
5qNCA, NET22, C5orf7, JMJD1B, lysine (K)-specific demethylase 3B

Application
ELISA (1:2000-1:10000), WB (1:1000-1:5000), IHC (1:50-1:200)

SAC0002

User Guide & MSDS

[User Guide]*
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DNA Methylation Antibody Panel Pack
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