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Intracellular Kinase & Adaptor Protein Antibodies

After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

In the case of receptor tyrosine kinases, the intracellular domain of the receptor itself possesses tyrosine kinase activity and is able to phosphorylate and activate itself. This phosphorylated residue then serves as a docking site for adaptor proteins, which initiate activation and signaling by a cascade of protein kinases. These adaptor proteins bind the phosphorylated receptor via specific protein domains, such as SH2 and SH3 domains. These signaling pathways generally culminate in activation of transcription factors in the nucleus, which alter transcription and gene expression.

A well-known pathway of intracellular kinases is the mitogen-activated protein kinase (MAPK) pathway, which involves successive phosphorylation and activation of the serine/threonine protein kinases Ras, Raf, MEK and MAPK or extracellular signal-regulated kinase (ERK). ERK then translocates to the nucleus and activates transcription factors, such as Myc. The constitutive activation of this and other signaling pathways has been implicated in cancer progression, as the unattenuated signal can lead to uncontrolled cellular proliferation. Other important kinase signaling pathways include the phosphaditylinositol-3-phosphate kinase (PI3K) and Protein Kinase B (AKT) pathway and the p38 signaling pathways. In the case of signals mediated by G-protein coupled receptors, G-proteins are the intracellular adaptor proteins bound to the receptors cytoplasmic domain which initiate the signal. The cyclic AMP and phosphaditylinositol pathways are the major signaling pathways that mediate signaling downstream of G-protein coupled receptors.

What makes buying antibodies from EpiGentek different?

At EpiGentek, we supply a collection of over 20,000 individual high-quality antibodies for our customers to ensure that our research customers find exactly what they need for their studies. In addition, we offer a variety of other benefits to help our customers in terms of affordability, convenience, and reliability. See why working with EpiGentek for your antibodies is the right choice:

  • No Shipping & Handling Costs: we’ve waived all shipping and handling fees on our antibodies and antibody panel packs when selecting 2-day shipping (trial sizes not applicable).
  • 100% Application Guarantee: your purchased antibodies are covered for 6-months past the date of purchase.
  • Multiple Conjugates: we carry biotin, FITC and HRP conjugates for nearly all targets.
  • Trial Sizes Available: 10 & 20 µg options available on over 5,000 antibodies in our catalog.

Result Pages: [<< Prev]   1  2  3  4  5 ...  [Next >>]  Displaying 21 to 40 (of 998 products)
AKT2 Polyclonal Antibody
AKT2 Polyclonal Antibody

Application: ELISA, IF, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human, Rat
Trial Size Available: Yes
A56166-02020 µgView
A56166-05050 µgView
A56166-100100 µgView
Antibodies
AKT2 Polyclonal Antibody, Biotin Conjugated
AKT2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A56169-05050 µgView
A56169-100100 µgView
Antibodies
AKT2 Polyclonal Antibody, FITC Conjugated
AKT2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A56168-05050 µgView
A56168-100100 µgView
Antibodies
AKT2 Polyclonal Antibody, HRP Conjugated
AKT2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A56167-05050 µgView
A56167-100100 µgView
Antibodies
ANK3 Polyclonal Antibody
ANK3 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A69875-02020 µgView
A69875-05050 µgView
A69875-100100 µgView
Antibodies
ANK3 Polyclonal Antibody, Biotin Conjugated
ANK3 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69878-05050 µgView
A69878-100100 µgView
Antibodies
ANK3 Polyclonal Antibody, FITC Conjugated
ANK3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69877-05050 µgView
A69877-100100 µgView
Antibodies
ANK3 Polyclonal Antibody, HRP Conjugated
ANK3 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69876-05050 µgView
A69876-100100 µgView
Antibodies
APPL1 Polyclonal Antibody
APPL1 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Cell Metabolism, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A68030-02020 µgView
A68030-05050 µgView
A68030-100100 µgView
Antibodies
APPL1 Polyclonal Antibody, Biotin Conjugated
APPL1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Metabolism, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68033-05050 µgView
A68033-100100 µgView
Antibodies
APPL1 Polyclonal Antibody, FITC Conjugated
APPL1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Metabolism, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68032-05050 µgView
A68032-100100 µgView
Antibodies
APPL1 Polyclonal Antibody, HRP Conjugated
APPL1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Metabolism, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68031-05050 µgView
A68031-100100 µgView
Antibodies
ARHGAP11A Polyclonal Antibody
ARHGAP11A Polyclonal Antibody

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A65518-02020 µgView
A65518-05050 µgView
A65518-100100 µgView
Antibodies
ARHGAP11A Polyclonal Antibody, Biotin Conjugated
ARHGAP11A Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A65521-05050 µgView
A65521-100100 µgView
Antibodies
ARHGAP11A Polyclonal Antibody, FITC Conjugated
ARHGAP11A Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A65520-05050 µgView
A65520-100100 µgView
Antibodies
ARHGAP11A Polyclonal Antibody, HRP Conjugated
ARHGAP11A Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A65519-05050 µgView
A65519-100100 µgView
Antibodies
ARHGAP19 Polyclonal Antibody
ARHGAP19 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A55427-02020 µgView
A55427-05050 µgView
A55427-100100 µgView
Antibodies
ARHGAP19 Polyclonal Antibody, Biotin Conjugated
ARHGAP19 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A55430-05050 µgView
A55430-100100 µgView
Antibodies
ARHGAP19 Polyclonal Antibody, FITC Conjugated
ARHGAP19 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A55429-05050 µgView
A55429-100100 µgView
Antibodies
ARHGAP19 Polyclonal Antibody, HRP Conjugated
ARHGAP19 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A55428-05050 µgView
A55428-100100 µgView
Antibodies
Result Pages: [<< Prev]   1  2  3  4  5 ...  [Next >>]  Displaying 21 to 40 (of 998 products)
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