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Intracellular Kinase & Adaptor Protein Antibodies

After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

In the case of receptor tyrosine kinases, the intracellular domain of the receptor itself possesses tyrosine kinase activity and is able to phosphorylate and activate itself. This phosphorylated residue then serves as a docking site for adaptor proteins, which initiate activation and signaling by a cascade of protein kinases. These adaptor proteins bind the phosphorylated receptor via specific protein domains, such as SH2 and SH3 domains. These signaling pathways generally culminate in activation of transcription factors in the nucleus, which alter transcription and gene expression.

A well-known pathway of intracellular kinases is the mitogen-activated protein kinase (MAPK) pathway, which involves successive phosphorylation and activation of the serine/threonine protein kinases Ras, Raf, MEK and MAPK or extracellular signal-regulated kinase (ERK). ERK then translocates to the nucleus and activates transcription factors, such as Myc. The constitutive activation of this and other signaling pathways has been implicated in cancer progression, as the unattenuated signal can lead to uncontrolled cellular proliferation. Other important kinase signaling pathways include the phosphaditylinositol-3-phosphate kinase (PI3K) and Protein Kinase B (AKT) pathway and the p38 signaling pathways. In the case of signals mediated by G-protein coupled receptors, G-proteins are the intracellular adaptor proteins bound to the receptors cytoplasmic domain which initiate the signal. The cyclic AMP and phosphaditylinositol pathways are the major signaling pathways that mediate signaling downstream of G-protein coupled receptors.

What makes buying antibodies from EpiGentek different?

At EpiGentek, we supply a collection of over 20,000 individual high-quality antibodies for our customers to ensure that our research customers find exactly what they need for their studies. In addition, we offer a variety of other benefits to help our customers in terms of affordability, convenience, and reliability. See why working with EpiGentek for your antibodies is the right choice:

  • No Shipping & Handling Costs: we’ve waived all shipping and handling fees on our antibodies and antibody panel packs when selecting 2-day shipping (trial sizes not applicable).
  • 100% Application Guarantee: your purchased antibodies are covered for 6-months past the date of purchase.
  • Multiple Conjugates: we carry biotin, FITC and HRP conjugates for nearly all targets.
  • Trial Sizes Available: 10 & 20 µg options available on over 5,000 antibodies in our catalog.

Result Pages: [<< Prev]  ... 16  17  18  19  20 ...  [Next >>]  Displaying 301 to 320 (of 1169 products)
GDI2 Polyclonal Antibody
GDI2 Polyclonal Antibody

Application: ELISA, WB
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A51496-02020 µgView
A51496-05050 µgView
A51496-100100 µgView
Antibodies
GDI2 Polyclonal Antibody
GDI2 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human, Mouse
Trial Size Available: Yes
A50237-02020 µgView
A50237-05050 µgView
A50237-100100 µgView
Antibodies
GDI2 Polyclonal Antibody, Biotin Conjugated
GDI2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A50240-05050 µgView
A50240-100100 µgView
Antibodies
GDI2 Polyclonal Antibody, Biotin Conjugated
GDI2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A51493-05050 µgView
A51493-100100 µgView
Antibodies
GDI2 Polyclonal Antibody, FITC Conjugated
GDI2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A51494-05050 µgView
A51494-100100 µgView
Antibodies
GDI2 Polyclonal Antibody, FITC Conjugated
GDI2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A50239-05050 µgView
A50239-100100 µgView
Antibodies
GDI2 Polyclonal Antibody, HRP Conjugated
GDI2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A50238-05050 µgView
A50238-100100 µgView
Antibodies
GDI2 Polyclonal Antibody, HRP Conjugated
GDI2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A51495-05050 µgView
A51495-100100 µgView
Antibodies
GIMAP7 Polyclonal Antibody
GIMAP7 Polyclonal Antibody

Application: ELISA, WB
Areas of Research: Immunology & Inflammation, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A51049-02020 µgView
A51049-05050 µgView
A51049-100100 µgView
Antibodies
GIMAP7 Polyclonal Antibody, Biotin Conjugated
GIMAP7 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Immunology & Inflammation, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A51052-05050 µgView
A51052-100100 µgView
Antibodies
GIMAP7 Polyclonal Antibody, FITC Conjugated
GIMAP7 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Immunology & Inflammation, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A51051-05050 µgView
A51051-100100 µgView
Antibodies
GIMAP7 Polyclonal Antibody, HRP Conjugated
GIMAP7 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Immunology & Inflammation, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A51050-05050 µgView
A51050-100100 µgView
Antibodies
GIT2 Polyclonal Antibody
GIT2 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A64646-02020 µgView
A64646-05050 µgView
A64646-100100 µgView
Antibodies
GIT2 Polyclonal Antibody
GIT2 Polyclonal Antibody new product

Application: WB
Areas of Research: Intracellular Kinase & Adaptor Protein Antibodies
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A72646-05050 µlView
A72646-100100 µlView
Antibodies
GIT2 Polyclonal Antibody, Biotin Conjugated
GIT2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A64649-05050 µgView
A64649-100100 µgView
Antibodies
GIT2 Polyclonal Antibody, FITC Conjugated
GIT2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A64648-05050 µgView
A64648-100100 µgView
Antibodies
GIT2 Polyclonal Antibody, HRP Conjugated
GIT2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Trafficking, Cellular Structure, Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A64647-05050 µgView
A64647-100100 µgView
Antibodies
GKAP1 Polyclonal Antibody
GKAP1 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A59246-02020 µgView
A59246-05050 µgView
A59246-100100 µgView
Antibodies
GKAP1 Polyclonal Antibody, Biotin Conjugated
GKAP1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A59247-05050 µgView
A59247-100100 µgView
Antibodies
GKAP1 Polyclonal Antibody, FITC Conjugated
GKAP1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A59248-05050 µgView
A59248-100100 µgView
Antibodies
Result Pages: [<< Prev]  ... 16  17  18  19  20 ...  [Next >>]  Displaying 301 to 320 (of 1169 products)
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