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BisulPlus Loci 5mC & 5hmC Detection PCR kit

Intracellular Kinase & Adaptor Protein Antibodies

After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

In the case of receptor tyrosine kinases, the intracellular domain of the receptor itself possesses tyrosine kinase activity and is able to phosphorylate and activate itself. This phosphorylated residue then serves as a docking site for adaptor proteins, which initiate activation and signaling by a cascade of protein kinases. These adaptor proteins bind the phosphorylated receptor via specific protein domains, such as SH2 and SH3 domains. These signaling pathways generally culminate in activation of transcription factors in the nucleus, which alter transcription and gene expression.

A well-known pathway of intracellular kinases is the mitogen-activated protein kinase (MAPK) pathway, which involves successive phosphorylation and activation of the serine/threonine protein kinases Ras, Raf, MEK and MAPK or extracellular signal-regulated kinase (ERK). ERK then translocates to the nucleus and activates transcription factors, such as Myc. The constitutive activation of this and other signaling pathways has been implicated in cancer progression, as the unattenuated signal can lead to uncontrolled cellular proliferation. Other important kinase signaling pathways include the phosphaditylinositol-3-phosphate kinase (PI3K) and Protein Kinase B (AKT) pathway and the p38 signaling pathways. In the case of signals mediated by G-protein coupled receptors, G-proteins are the intracellular adaptor proteins bound to the receptors cytoplasmic domain which initiate the signal. The cyclic AMP and phosphaditylinositol pathways are the major signaling pathways that mediate signaling downstream of G-protein coupled receptors.

What makes buying antibodies from EpiGentek different?

At EpiGentek, we supply a collection of over 20,000 individual high-quality antibodies for our customers to ensure that our research customers find exactly what they need for their studies. In addition, we offer a variety of other benefits to help our customers in terms of affordability, convenience, and reliability. See why working with EpiGentek for your antibodies is the right choice:

  • No Shipping & Handling Costs: we’ve waived all shipping and handling fees on our antibodies and antibody panel packs when selecting 2-day shipping (trial sizes not applicable).
  • 100% Application Guarantee: your purchased antibodies are covered for 6-months past the date of purchase.
  • Multiple Conjugates: we carry biotin, FITC and HRP conjugates for nearly all targets.
  • Trial Sizes Available: 10 & 20 µg options available on over 5,000 antibodies in our catalog.

Result Pages: [<< Prev]  ... 11  12  13  14  15 ...  [Next >>]  Displaying 261 to 280 (of 1169 products)
DTNBP1 Polyclonal Antibody, FITC Conjugated
DTNBP1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69061-05050 µgView
A69061-100100 µgView
Antibodies
DTNBP1 Polyclonal Antibody, HRP Conjugated
DTNBP1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69060-05050 µgView
A69060-100100 µgView
Antibodies
DYRK3 Polyclonal Antibody
DYRK3 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
Trial Size Available: Yes
A62450-02020 µgView
A62450-05050 µgView
A62450-100100 µgView
Antibodies
DYRK3 Polyclonal Antibody, Biotin Conjugated
DYRK3 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A62453-05050 µgView
A62453-100100 µgView
Antibodies
DYRK3 Polyclonal Antibody, FITC Conjugated
DYRK3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A62452-05050 µgView
A62452-100100 µgView
Antibodies
DYRK3 Polyclonal Antibody, HRP Conjugated
DYRK3 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A62451-05050 µgView
A62451-100100 µgView
Antibodies
DYRK4 Polyclonal Antibody
DYRK4 Polyclonal Antibody new product

Application: WB
Areas of Research: Intracellular Kinase & Adaptor Protein Antibodies
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
A71971-05050 µlView
A71971-100100 µlView
Antibodies
DYRK4 Polyclonal Antibody
DYRK4 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A58878-02020 µgView
A58878-05050 µgView
A58878-100100 µgView
Antibodies
DYRK4 Polyclonal Antibody, Biotin Conjugated
DYRK4 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A58879-05050 µgView
A58879-100100 µgView
Antibodies
DYRK4 Polyclonal Antibody, FITC Conjugated
DYRK4 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A58880-05050 µgView
A58880-100100 µgView
Antibodies
DYRK4 Polyclonal Antibody, HRP Conjugated
DYRK4 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A58881-05050 µgView
A58881-100100 µgView
Antibodies
EFR3B Polyclonal Antibody
EFR3B Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A68206-02020 µgView
A68206-05050 µgView
A68206-100100 µgView
Antibodies
EFR3B Polyclonal Antibody, Biotin Conjugated
EFR3B Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68209-05050 µgView
A68209-100100 µgView
Antibodies
EFR3B Polyclonal Antibody, FITC Conjugated
EFR3B Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68208-05050 µgView
A68208-100100 µgView
Antibodies
EFR3B Polyclonal Antibody, HRP Conjugated
EFR3B Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68207-05050 µgView
A68207-100100 µgView
Antibodies
ERAS Polyclonal Antibody
ERAS Polyclonal Antibody

Application: ELISA, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A52309-02020 µgView
A52309-05050 µgView
A52309-100100 µgView
Antibodies
ERAS Polyclonal Antibody, Biotin Conjugated
ERAS Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A52306-05050 µgView
A52306-100100 µgView
Antibodies
ERAS Polyclonal Antibody, FITC Conjugated
ERAS Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A52307-05050 µgView
A52307-100100 µgView
Antibodies
ERAS Polyclonal Antibody, HRP Conjugated
ERAS Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A52308-05050 µgView
A52308-100100 µgView
Antibodies
FAM20C Polyclonal Antibody
FAM20C Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A70015-02020 µgView
A70015-05050 µgView
A70015-100100 µgView
Antibodies
Result Pages: [<< Prev]  ... 11  12  13  14  15 ...  [Next >>]  Displaying 261 to 280 (of 1169 products)
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