Epigentek's anti-5-hydroxymethyluridine recognizes 5-hydroxymethyluridine, which is created by the oxidation of thymine by ionizing radiation or reactive oxygen species. This oxidation effect causes changes in gene expression, mutations, and chromosomal instability -- all of which play a role in cancer, autoimmune disease, and aging. 5-hydroxymethyluridine is a potential biomarker for female breast, colon, and rectal cancers, being present at elevated levels, possibly due to impaired DNA repair mechanisms.
Goat Polyclonal Antibody (pAb)
Serum - liquid
0.09% Sodium Azide (NaN3)
Store at 4°C or at -20°C if preferred; storage in frost-free freezers is not recommended; this product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
Should this product contain a precipitate we recommend microcentrifugation before use. For maximum recovery of the product, centrifuge the vial prior to opening the cap.
5-hmdU antibody, 5-hydroxymethyl 2’ deoxyuridine antibody
Applications & Suggested Dilutions