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Histone Modification Antibodies

Histone Modification Antibodies

Histone modification antibodies are used to investigate epigenetic modifications to histones such as acetylation, methylation, and phosphorylation. Histone methylation is associated with transcriptional repression or activation via the transfer of methyl groups to lysine or arginine residues of histone proteins and is crucial to studying epigenetic gene regulation with the use of histone methylation antibodies. Histone methyltransferases (HMTs) are responsible for catalyzing this process. Similarly, histone acetylation antibodies can be used to study chromatin remodeling and epigenetic gene regulation that occurs as a result of histone acetylation. This histone modification is defined as the addition of an acetyl group to lysine residues of histone proteins by enzymes known as histone acetyltransferases (HATs), and is associated with gene activation and expression.
Histone Methylation (Lysine) Antibodies
Histone lysine methylation is a well-established transcriptional mechanism for regulating gene expression in eukaryotic cells. Histone N-terminal tails are susceptible to post-translational modifications (PTMs) and can influence many biological processes including transcription, replication, and chromosome maintenance. Methylation of lysine residues within histones is tightly regulated by methyltransferases (KMTs) and demethylases (KDMs) to preserve cell fate and genomic stability.

Histone Methylation (Arginine) Antibodies
Arginine methylation is a broadly expressed post-translational modification that occurs on both nuclear and cytoplasmic proteins. It is especially profuse on proteins that can shuttle continuously between the nucleus and the cytoplasm. The family of protein arginine methyltransferases (PRMTs) catalyzes methylation reactions, including target histones. Histone arginine methylation, which transpires on the tails of histone, can encourage or prevent the docking of key transcriptional effe...

Other Histone Methylation Antibodies
Histone methylation occurs with the addition of a methyl group to the amino-terminal tails of histone proteins. Depending on how many methyl groups are added and which amino acid residue is modified, histone methylation can have a positive or negative effect on gene transcription. Histone methyltransferases (HMTs) are enzymes that catalyze the addition of methyl groups to histone proteins, while histone demethylases (HDMs) remove these methyl groups. This process is important f...

Histone Acetylation Antibodies
Histone acetylation is defined by the addition of an acetyl functional group to the lysine residues of the N-terminal tail and its status can be studied with the use of histone acetylation antibodies. Evidence shows histone acetylation is highly involved in gene regulation and histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity affect the availability of chromatin to gene transcription.

Histone Deacetylation Antibodies
Histone deacetylation, the process by which histone deacetylase (HDAC) catalyzes the removal of the acetyl functional group from histones, can be investigated using HDAC antibodies. Decreased levels of acetylation as a result of HDAC activity has been linked to repression of gene expression due to the condensed state of chromatin, referred to as heterochromatin.

Other Histone Acetylation Antibodies
The process of histone acetylation at lysine residues by histone acetyltransferase (HAT) is an important epigenetic marker and can be measured with the use of histone lysine acetylation antibodies. Acetylation of histones reduces the interaction of histone N termini with the phosphate groups of DNA, thereby loosening chromatin and opening it up for increased gene transcription. Acetylation of H3K14, for instance, has been linked to transcriptional activation and specifically DNA repair...

Histone Phosphorylation Antibodies
Antibodies that detect phosphorylated target proteins help researchers to understand the role phosphorylation plays in cellular processes. Phosphorylation can turn on and off numerous protein enzymes by adding a phosphate group to the protein, thereby affecting their activity and function.

Ubiquitination & SUMOylation Antibodies
Ubiquitination is the process by which ubiquitin is attached to a substrate protein after it has been made. It has been known to affect proteins by altering cellular location, impacting protein activity, and adjusting protein-protein interactions. Research shows that sumoylation regulates protein-protein interactions and subcellular targeting and is involved in numerous processes such as nuclear-cytosolic transport, apoptosis, transcriptional regulation, response to stress, protein stability,...

Other Histone Antibodies
Other histone antibodies can be used to study the core nucleosomal histones, the histones regularly associated with DNA in chromatin, as well as non-canonical histone variants that often can substitute for the core histones under diverse physiological and environmental conditions. The core nucleosomal histones are mostly incorporated into chromatin during DNA replication, while histone variants can be integrated throughout the cell cycle. Adjoining of these histone variants can alter chromatin structure and affect transcription, DNA replication and other biological processes, and can influence embryonic development and cell fate decisions. Some well-known histone variants include H2A.X, H2A.Z and H3.3.

Result Pages:  1  2  3  4  5 ...  [Next >>]  Displaying 1 to 20 (of 1248 products)
Image Description Cat. No. Size Price
19S Proteasome (ADRM1) Polyclonal Antibody
19S Proteasome (ADRM1) Polyclonal Antibody

Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
A-8505-02525 µl $143.00 Discontinued
A-8505-100100 µl $452.00 Discontinued
Antibodies
AOF2 Monoclonal Antibody [2E7]
AOF2 Monoclonal Antibody [2E7]

Application: ELISA, IHC, WB
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG2a Kappa
Purification: Affinity Purified
Reactivity: Human
A-3114-100100 µg $452.00 Add to Cart
Antibodies
ARD1 Monoclonal Antibody [4B7-H4]
ARD1 Monoclonal Antibody [4B7-H4]

Application: ELISA, IF, WB
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG1 Kappa
Purification: Affinity Purified
Reactivity: Human
A-4118-100100 µg $452.00 Add to Cart
Antibodies
ARIH2 Monoclonal Antibody [1C3]
ARIH2 Monoclonal Antibody [1C3]

Application: ELISA, WB
Areas of Research: Other Histone Modification
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgM Kappa
Purification: Affinity Purified
Reactivity: Human
A-2135-200200 µl $452.00 Add to Cart
Antibodies
AROS Polyclonal Antibody [AT135]
AROS Polyclonal Antibody [AT135]

Application: WB
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Purification: Affinity Purified
Reactivity: Human
A-0511-100100 µg $534.00 Add to Cart
Antibodies
ASB10 Polyclonal Antibody
ASB10 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66798-05050 µg $249.00 Add to Cart
A66798-100100 µg $349.00 Add to Cart
Antibodies
ASB10 Polyclonal Antibody, Biotin Conjugated
ASB10 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66801-05050 µg $249.00 Add to Cart
A66801-100100 µg $349.00 Add to Cart
Antibodies
ASB10 Polyclonal Antibody, FITC Conjugated
ASB10 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66800-05050 µg $249.00 Add to Cart
A66800-100100 µg $349.00 Add to Cart
Antibodies
ASB10 Polyclonal Antibody, HRP Conjugated
ASB10 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66799-05050 µg $249.00 Add to Cart
A66799-100100 µg $349.00 Add to Cart
Antibodies
ASB11 Monoclonal Antibody [4D11]
ASB11 Monoclonal Antibody [4D11]

Application: ELISA, WB
Areas of Research: Other Histone Modification
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG1 Kappa
Purification: Affinity Purified
Reactivity: Human
A-8118-100100 µg $452.00 Add to Cart
Antibodies
ASB11 Polyclonal Antibody
ASB11 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67066-05050 µg $249.00 Add to Cart
A67066-100100 µg $349.00 Add to Cart
Antibodies
ASB11 Polyclonal Antibody, Biotin Conjugated
ASB11 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67069-05050 µg $249.00 Add to Cart
A67069-100100 µg $349.00 Add to Cart
Antibodies
ASB11 Polyclonal Antibody, FITC Conjugated
ASB11 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67068-05050 µg $249.00 Add to Cart
A67068-100100 µg $349.00 Add to Cart
Antibodies
ASB11 Polyclonal Antibody, HRP Conjugated
ASB11 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67067-05050 µg $249.00 Add to Cart
A67067-100100 µg $349.00 Add to Cart
Antibodies
ASB13 Polyclonal Antibody
ASB13 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58178-05050 µg $249.00 Add to Cart
A58178-100100 µg $349.00 Add to Cart
Antibodies
ASB13 Polyclonal Antibody, Biotin Conjugated
ASB13 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58179-05050 µg $249.00 Add to Cart
A58179-100100 µg $349.00 Add to Cart
Antibodies
ASB13 Polyclonal Antibody, FITC Conjugated
ASB13 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58180-05050 µg $249.00 Add to Cart
A58180-100100 µg $349.00 Add to Cart
Antibodies
ASB13 Polyclonal Antibody, HRP Conjugated
ASB13 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58181-05050 µg $249.00 Add to Cart
A58181-100100 µg $349.00 Add to Cart
Antibodies
ASB2 Monoclonal Antibody [1E5]
ASB2 Monoclonal Antibody [1E5]

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG2b Kappa
Purification: Affinity Purified
Reactivity: Human
A-8101-100100 µg $452.00 Add to Cart
Antibodies
ASB6 Polyclonal Antibody
ASB6 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58182-05050 µg $249.00 Add to Cart
A58182-100100 µg $349.00 Add to Cart
Antibodies
Result Pages:  1  2  3  4  5 ...  [Next >>]  Displaying 1 to 20 (of 1248 products)
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