Background Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Description Histone H3K4ac (Acetyl H3K4) Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Specificity Human, Mouse, Rat, Broad Range
Isotype IgG
Uniprot ID Q16695/P68431
Purification Affinity Purified
Immunogen A synthetic acetylated peptide around K4 of human Histone H3 (NP_003484.1).
Storage Shipped at 4°C. Shipped at 4°C. Store at -20°C. Avoid multiple freeze / thaw cycles.
Alternative Names H3.4; H3/g; H3FT; H3t; HIST3H3; Histone H3; HIST1H3A
Application WB, IF/ICC, ChIP, ELISA; Recommended dilution: WB 1:500 - 1:1000, IF/ICC 1:50 - 1:100, ChIP 5μg antibody for 5μg-10μg of Chromatin, ELISA - recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
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