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Histone Acetylation

Modulators and inhibitors are used in enzyme inhibition assays to study histone acetylation, or the addition of an acetyl group on a histone, which then affects the regulation of transcription through chromatin remodeling. Certain epigenetic modulators and inhibitors specific to histone acetylation studies have been shown to inhibit histone acetyltransferases (HATs) such as p300/CBP associated factor histone acetyltransferase, inhibit the transcription factor NF kappa B, promote apoptosis through caspase-3 activation, and even exhibit anti-carcinogenic and anti-inflammatory properties.
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