Extracellular signal-regulated protein kinases 1 and 2 (Erk1/2) belong to the mitogen-activated protein kinase (MAPK) super family associated with cell proliferation and apoptosis. Erk1/2 may be activated by a variety of extracellular stimuli including mitogen, growth factors, and cytokines. After Erks have been activated, they will proceed to phosphorylate several other downstream molecules that are involved in a range of cell activities. The MAPK signaling pathway is a frequent target for oncology-related drug development.
Rabbit polyclonal antibody to Erk1/2
Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Synthetic peptide corresponding to a portion of rat Erk1. The sequence is completely conserved in hamster.
Human, Mouse, Rat, Bovine, Sheep, Chicken, Drosophila, Xenopus
Protein A-affinity purified
Store at -20°C. Avoid multiple freeze/thaw cycles.
MAPK2/3, MAP kinase 2/3
FC (10 µg/ml), IHC (1:50), IP, WB (1:1000, colorimetric)
Fig. 1. Western blot analysis of human A431 fibroblast cell lysate, probed with Erk1/2 Polyclonal Antibody.
Fig. 2. Immunohistochemistry analysis: Human placenta tissue stained with Erk1/2 Polyclonal Antibody at 10µg/ml.