BackgroundThis gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.
DescriptionECH1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDQ13011
PurificationAffinity Purified
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human ECH1 (NP_001389.2)
StorageShipped at 4°C. Store at -20°C. Avoid freeze / thaw cycles.
Alternative NamesECH1; HPXEL
ApplicationELISA, IHC-P, WB; Recommended dilution: WB 1:500 - 1:2000, IHC-P 1:50 - 1:200
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