Alternative Names2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-oneDescriptionPARP Inhibitor XI, DR2313 is a water soluble and brain-permeable pyrimidinone compound that functions as a Poly(ADP-ribose) polymerase inhibitor. Poly(ADP-ribose) polymerases, known as PARP, function by triggering DNA repair mechanisms and activating apoptosis in damaged cells. Studies show that DR2313 is a NAD+ utilizing enzyme which competitively inhibits Poly(ADP-ribose) polymerases but does not display selectivity among PARP-1 and PARP-2. In addition, in vitro studies of cerebral ischemia exhibiting an overactivation of PARP can be reduced by introducing DR2313CAS Number284028-90-6Chemical FormulaC8H10N2OSMolecular Weight182.2
Size10 mgPurity>98%SolubilityH2OStorage Temp-20°C