BackgroundThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. Diseases associated with TNFSF13B include Sialadenitis and Hypersensitivity Reaction Type Ii Disease.
DescriptionRat monoclonal antibody to BAFF, Clone BUFFY1 (FITC conjugated)
FormulationLiquid. In PBS containing 0.02% sodium azide.
ImmunogenRecombinant human soluble BAFF (aa 83-285)
SpecificityHuman
IsotypeIgG2a
Uniprot IDQ9Y275
StorageStore at 4°C. Avoid multiple freeze/thaw cycles.
Alternative NamesB cell-activating factor, BLyS, TALL-1, THANK, zTNF4, TNFSF 13B/20, CD257
ApplicationFlow Cytometry, ICC, WB