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Aurora A Inhibitor I

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Application: EnzymeInhibition
Molecular Weight: 100-500
Research Area: Histone Phosphorylation
Solubility: DMSO
100% Guarantee: 6 months
Catalog No.SizePriceQty
M75000-15 mg $619.00  Discontinued
Availability: Discontinued 
Product Overview

Alternative Names
4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide

Description
4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide is a cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112 - 514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).

CAS Number
443797-96-4

Chemical Formula
C15H12F2N6O3S •CH3CN

Molecular Weight
435.4

Size
5 mg

Purity
≥97%

Solubility
Soluble in DMSO

Storage Temp
-20°C

User Guide & MSDS

[User Guide]*
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