The Set1/COMPASS histone methyltransferase complex contains the SET1 histone methyltransferase protein. It functions as a transcriptional co-activator and methylates histone H3 at Lys4 (H3K4). Although first identified in yeast, SET1-related proteins are also found within mammals, including proteins SET1A, SET1B, MLL1, MLL2, MLL3, and MLL4. These proteins work together in a complex to methylate histone H3 at Lys4. In addition, SET1/COMPASS histone methyltransferase complexes are thought to play a role in leukemogenesis due to a significant amount of hematological malignancies containing MLL translocations.
SET1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit
Liquid. 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, PH 7.4
Protein G purified
Recombinant human Histone-lysine N-methyltransferase SETD1A protein (188-304AA)
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Histone-lysine N-methyltransferase SETD1A (EC 188.8.131.52) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1), SETD1A, KIAA0339 KMT2F SET1 SET1A
ELISA, IHC; Recommended dilution: IHC:1:20-1:200