Backgroundp300, also known as EP300 or E1A binding protein p300, is a universally expressed, reasonably stable nuclear phosphorprotein that is closely related to CBP (or CREB). CBP and p300 are identified as transcriptional coactivators that can directly interact with several different DNA-binding transcription factors including nuclear hormone receptors, CREB, c-Fos, C-Jun/v-Jun, c-Myb/v-Myb, TFIIB and MyoD. These two proteins have been known to exhibit histone acetyltransferase (HAT) activity and can acetylate all four core histones in the nucleosome. It is believed that both p300 and CBP may be directly involved in activating chromatin for transcription.
Descriptionp300 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDQ09472
PurificationAffinity Purified
ImmunogenSynthesized peptide derived from Human p300 around the non-phosphorylation site of S89
StorageShipped at 4°C. Aliquot store at -20°C . Avoid repeated freeze / thaw cycles.
Alternative NamesCREBBP/EP300 inhibitory protein 1 antibody, P-300, Cyclic AMP responsive enhancer binding protein antibody, E1A associated protein p300 antibody, E1A binding protein p300 antibody, EC 2.3.1.48 antibody, EP300 antibody, Histone acetyltransferase p300 antibody, p300 HAT antibody, RB and P300 binding protein EID 1 antibody, Retinoblastoma protein associated protein antibody, RSTS2 antibody
ApplicationWB, IHC, ELISA; Recommended dilution: WB:1:500-1:2000, IHC:1:100-1:300, ELISA:1:5000
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