Histone H4K12ac (Acetyl H4K12) Polyclonal Antibody

Background
Histone H4- along with H2A, H2B, and H3- is involved in the structure of chromatin in eukaryotic cells. Histone H4 can undergo several different types of epigenetic modifications that influence cellular processes. These modifications including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation, occur on the N-terminal tail domains of histone H4, which results in remodeling of the nucleosome structure into an open conformation more accessible to transcription complexes. In most species, histone H4 is primarily acetylated at lysine 5, 8, 12, and 16. 

Description
Histone H4K12ac (Acetyl H4K12) Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Purification
Affinity Purified

Immunogen
Synthesized peptide derived from human Histone H4 around the acetylation site of K12.

Specificity
Human, Mouse, Rat, Monkey

Uniprot No
P62805

Isotype
IgG

Formulation 
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage
Store at -20°C or -80°C. Avoid repeated freeze

Alternative Names
H4K12ac antibody, H4K12a antibody

Application 
ELISA, IF, IHC, WB; Recommended dilution: WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000, ELISA:1:10000

VCU0006