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Annexin V Monoclonal Tag Antibody [VAA-33]

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Application: ELISA, FC
Areas of Research: Apoptosis & Cell Death
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG2a
Purification: Affinity Purified
Reactivity: Human
100% Guarantee: 6 months
Catalog No.SizePriceQty
A26006-1100 µg $539.00  Discontinued
Availability: Discontinued 
Product Overview

Description
Mouse Anti Human Annexin V specifically recognizes human Annexin V, a phospholipid binding protein which binds with high affinity and selectivity to phosphatidylserine (PS), in the presence of calcium. The translocation of PS from the cytosolic leaflet to the outer leaflet of the plasma membrane, due to a loss in plasma membrane asymmetry during apoptosis, acts as an in vivo signal for the removal of the dying cell by phagocytosis. Detection of PS using Annexin V therefore provides a reliable diagnostic tool for the indication of early programmed cell death. Annexin V has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Annexin V are associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions, and systemic sclerosis (SSc). Clone VAA-33 has been reported to work in western blotting applications.

Antibody Type
Monoclonal Antibody

Purification
Purified IgG - liquid

Immunogen
Recombinant Annexin V

Isotype
IgG2a

Size
100 µg

Formulation
Phosphate buffered saline. 0.09% Sodium Azide (NaN3) 

Specificity
Human

Storage
Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.

Handling Recommendations
Should this product contain a precipitate we recommend microcentrifugation before use. For maximum recovery of the products, centrifuge the vial prior to opening the cap. 

Applications & Suggested Dilutions
ELISA; Flow Cytometry: (Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Method sheets are available on request).

User Guide & MSDS

[User Guide]*
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