Sumoylation

Introduction

SUMOylation is a post-translational modification process that involves the covalent attachment of small ubiquitin-like modifier (SUMO) proteins to lysine residues on target proteins. This process is reversible and can be regulated by enzymes called SUMO proteases.

Regulation of Cellular Processes

SUMOylation plays a role in the regulation of various cellular processes, including transcription, protein stability, nuclear-cytosolic transport, protein-protein interactions, cellular localization, apoptosis, DNA repair, stress response, and cell cycle progression. Dysregulation of SUMOylation has been linked to the development of various diseases. For example, SUMOylation of certain transcription factors is essential for proper gene regulation in cancer cells, and abnormal SUMOylation of proteins has been observed in the brains of individuals with neurodegenerative diseases such as Alzheimer's and Parkinson's.

Detection and Implications

The detection of in vivo protein SUMOylation can provide insight into the function of proteins and their role in various cellular processes. This can be useful for understanding the underlying mechanisms of diseases in which SUMOylation is disrupted and for identifying potential therapeutic targets for these diseases. Additionally, studying SUMOylation may provide insight into how to target and modulate specific proteins in order to manipulate their function.

Summary

  • SUMOylation is a post-translational modification process involving the attachment of SUMO proteins to target proteins.
  • It is involved in the regulation of various cellular processes and its dysregulation has been linked to the development of various diseases.
  • Detection of in vivo protein SUMOylation can provide insight into protein function and the underlying mechanisms of diseases.
  • Understanding SUMOylation may provide insight into targeting and modulating specific proteins for therapeutic purposes.
Result Pages:  1  Displaying 1 to 3 (of 3 products)
1064 - You have an error in your SQL syntax; check the manual that corresponds to your MySQL server version for the right syntax to use near 'LIMIT 0,20' at line 4

select p.products_model, pd.products_name, p.products_image, p.products_date_added, p.products_id, p.manufacturers_id, p.products_price, p.products_master, p.products_master_status, p.products_tax_class_id, IF(s.status, s.specials_new_products_price, NULL) as specials_new_products_price, IF(s.status, s.specials_new_products_price, p.products_price) as final_price from ((products_description pd, products p) left join manufacturers m on p.manufacturers_id = m.manufacturers_id, products_to_categories p2c) left join specials s on p.products_id = s.products_id LEFT JOIN products_filters_to_products pfpx ON p.products_id=pfpx.products_id LEFT JOIN products_filters pfx ON pfpx.products_filters_id=pfx.products_filters_id LEFT JOIN products_filters_categories pfcx ON pfx.products_filters_categories_id=pfcx.products_filters_categories_id where p.products_status = '1' and p.products_listing_status = '1' and p.products_id = p2c.products_id and pd.products_id = p2c.products_id and pd.language_id = '1' and p2c.categories_id IN (40) AND pfcx.products_filters_top_categories_id IN (9) group by p.products_id order by LIMIT 0,20

[TEP STOP]