(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione Diferuloylmethane Diferulylmethane
Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa; it is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. Curcumin has been shown to inhibit NF-κB (possibly thru inhibition of JNK; IC50=10 μM), blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase; IC50=8 μM), Cox-2 (cyclooxygenase-2; IC50=52 μM), the COP9 signalosome kinase (IC50=10 µM), and p300/CBP. This wide range of activities makes Curcumin an extremely useful tool for developing novel analogous molecules and discovering new uses for this naturally occurring compound.
Soluble in water, ethanol (10 mg/ml), DMSO (25 mg/ml) and acetic acid