Polycomb group (PcG) proteins form the multiprotein complexes that are important for the transcriptional repression of various genes involved in development and cell proliferation. RING1 is a PcG protein that contains the RING finger motif, a specific zinc-binding domain that is found in many regulatory proteins. It has been shown that RING1 interacts with transcription factor CP2 (TFCP2/CP2) and suppress the activity of CP2. Also, there is involvement of the gene RING1B in the specification of the anterior-posterior axis as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitinconjugating enzyme, as well as possess ubiquitin ligase activity.
Rabbit polyclonal antibody to RING1, ChIP-grade
Protein A purified
Mouse, rat, human
0.1% Sodium Azide, 0.1% gelatin, PBS
4°C, stable for 1 year from the date of shipment. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance
Ring1A antibody, E3 ubiquitin-protein ligase RING1 antibody, Polycomb complex protein RING1 antibody, RING finger protein 1 antibody, Rnf1 antibody, Transcription repressor Ring1A antibody
WB: 1:200-1:500, IF: 1:100-1:500, ELISA: 1:1000-1:2000, IP: 2 µg/106 cells
Fig. 1. WB analysis of RING1 Polyclonal Antibody with Ring1 overexpressed cell lysates (A-2021).