PRMT6, or Protein arginine N-methyltransferase 6, is part of the PRMT family that catalyzes the methylation of arginine residues. PRMT6 specifically coregulates gene expression by acting as an activator and repressor via dimethylation of Histone H3R2me2a. PRMT6 methylates several histones at various residues, particularly Histone H2AR3me, Histone H3K4me2, Histone H3K4me3, as well as Histone H4R3me. By transcriptionally repressing tumor suppressor genes, PRMT6 has been shown to regulate cell proliferation and senescence and, via interactions with Rev, Nucleocapsid protein p7, and Tat, PRMT6 might also be implicated in innate immunity against HIV-1.
Rabbit polyclonal antibody to PRMT6
Protein A purified
Positive in human
0.1% Sodium Azide, PBS
4ºC, stable for 6 months from the date of shipment. For long-term storage, aliquot and store at -20ºC. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance
ANM6_HUMAN antibody, Chromobox protein homolog 7 antibody, FLJ10559 antibody, FLJ51477 antibody, Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6 antibody, Histone-arginine N-methyltransferase PRMT6 antibody, HMT1 hnRNP methyltransferase like 6 antibody, HRMT1L6 antibody, OTTHUMP00000012633 antibody, PRMT 6 antibody, Protein arginine N methyltransferase 6 antibody
WB: 1:200-1:500, ELISA: 1:500-1:1000
Fig. 1. WB analysis of PRMT6 Polyclonal Antibody with NCI-460 cell lysates (A-3006).